Corpus Callosum Agenesis: Speech and Language Disorder

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Introduction: Corpus callosum agenesis is a rare congenital condition result from a fiberal malformation. Individuals with corpus callosum agenesis may have different symptoms. This study aims to introduce a rare condition and inform about ongoing assessment and treatment processes.

Methods: 1 participant diagnosed with corpus callosum agenesis who is 42 months was assessed with TEDİL and TİGE assessment tests and had speech and language therapy for 18 months. While therapy was continuing, the second evaluation was carried out.

Results: The participant was found to produce only 5-6 single words in the beginning of intervention besides exhibiting many of behavioral problems. With 18 month sessions, the participant was able to not only use more words, word combination and pragmatic gestures but also have eye contact, imitation skills and less behavioral problems.

Discussion And Conclusion: The results were similar to the ones in related studies which focus on corpus callosum agenesis which shows that the participant has had developmental delay and speech & language disorder. It is stated that intervention and assessment process is better conducted with multidisciplinary team


The Clinical Characteristics of Children with Agenesis of the Corpus Callosum

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Objective: To analyze the clinical features of children with agenesis of the corpus callosum in this study due to the lack description at present.

Method: This study retrospectively collected the case data of the agenesis of corpus callosum (ACC) hospitalized in Children’s Hospital Affiliated to Chongqing Medical University from January 2015 to October 2021.

Results: 1.Classification and typing characteristics: 1.1 Classification according to the absence of anatomical structure of corpus callosum: total absence of corpus callosum in 7 cases (5.8%); partial absent of corpus callosum in 80 cases (66.7%) ;Corpus callosum was thin in 33 cases (27.5%). 1.2 Classification according to presence of extra-callosal craniocerebral malformations:69 children with isolated ACC (57.5%); complex ACC with 51 cases (42.5%). 1.3 Classification based on extracranial structural malformations: 52 children (43.3%) with non-syndromic ACC. 68 cases (56.7%) with syndromic ACC. 2. Clinical features: 70 cases (58.3%) of Gross Developmental Delay, 50 cases (41.7%) of epilepsy, 44 cases (37.3%) of microcephaly, 41 cases (34.2%) of malnutrition, 20 cases (16.7%) of respiratory failure.

Conclusion: Children with agenesis of corpus callosum are often accompanied by abnormalities of other intracranial structures outside the corpus callosum and abnormal structure of extracranial organs. Children with agenesis of the corpus callosum often have neurological diseases, such as gross developmental delay, epilepsy. Secondly, the incidence of malnutrition is also high, especially the severe malnutrition. In addition, some children may also show respiratory failure, so it is necessary to be alert to the possibility of structural abnormalities of the respiratory system. The children with agenesis of the corpus callosum also have a family history of spontaneous abortion in their mothers, patients with neuropsychiatric diseases in their families, and the family history of early death.